Norwogonin, CAS 4443-09-8

Formulation: A solid

Formal Name: 5,7,8-trihydroxy-2-phenyl-4H-1-benzopyran-4-one

Purity: ≥95%

Formula Markup: C15H10O5

Formula Weight: 270,2

Shelf life (days): 1460

CAS Number: 4443-09-8

Notes: Norwogonin is a polyhydroxy flavone that has been found in S. baicalensis and has diverse biological activities, including antioxidant, antiviral, and anticancer properties.{46574,46575,46576} It scavenges ABTS (Item No. 27317) and 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals with IC50 values of 1.24 and 35.61 μg/ml, respectively, in cell-free assays.{46574} Norwogonin inhibits cytopathic effects induced by enterovirus 71 (EV71) in infected Vero cells (IC50 = 31.83 μg/ml).{46575} It reduces the viability of MDA-MB-231, BT-549, HCC70, and HCC1806 triple-negative breast cancer (TNBC) cells (IC50s = 32.24, 56.2, 39.05, and 37.3 μM, respectively) but not the non-tumorigenic cell lines MCF-10A and AG11132 (IC50s = >100 μM for both).{46576} Norwogonin induces cell cycle arrest at the G1 and G2/M phases and increases apoptosis in MDA-MB-231 cells in a concentration-dependent manner.

• Artikelnummer: CAY29227-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29227-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK