NSC 12, CAS 102586-30-1

Formulation: A crystalline solid

Formal Name: (3β)-24,24,24-trifluoro-23-(trifluoromethyl)-21-norchol-5-ene-3,20,23-triol

Purity: ≥98%

Formula Markup: C24H34F6O3

Formula Weight: 484,5

Shelf life (days): 1460

CAS Number: 102586-30-1

Notes: NSC 12 is an extracellular trap for fibroblast growth factor 2 (FGF2) that binds FGF2 (Kd = 51 µM) and interferes with its interaction with FGFR1, without affecting the ability of FGF2 to bind heparin or heparin sulfate proteoglycans (HSPGs).{32843} NSC 12 also binds several other, but not all, FGF isoforms with Kd values ranging between 16 and 120 µM, preventing them from forming HSPG/FGF/FGFR ternary complexes.{32843} NSC 12 inhibits FGF-dependent angiogenesis and tumor cell proliferation in vitro and reduces tumor growth in mice.{32843}

• Artikelnummer: CAY20117-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 20117-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK