O-Arachidonoyl Glycidol, CAS 439146-24-4

Formulation: A solution in methyl acetate

Formal Name: 5Z,8Z,11Z,14Z-eicosatetraenoic acid, oxiranylmethyl ester

Purity: ≥98%

Formula Markup: C23H36O3

Formula Weight: 360,5

Shelf life (days): 365

CAS Number: 439146-24-4

Notes: 2-Arachidonoyl glycerol (2-AG) is an endogenous ligand that binds to both central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors and is involved in the regulation of a broad range of neurotransmitter signalling functions with implications in neurodegenerative diseases, pain, cancer, and obesity.{15051} Levels of this endocannabinoid are regulated by hydrolysis to glycerol and arachidonic acid by the enzyme monoacylglycerol lipase. O-Arachidonoyl glycidol is a 2-arachidonoyl glycerol analog that blocks 2-oleoyl glycerol hydrolysis in the cytosolic and membrane fractions of rat cerebella with IC50 values of 4.5 and 19 µM, respectively.{15051} O-Arachidonoyl glycidol inhibits fatty acid amide hydrolase-catalyzed hydrolysis of arachidonoyl ethanolamide in the membrane fraction of rat cerebella with an IC50 value of 12 µM.{15051}

• Artikelnummer: CAY10010547-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10010547-50
• Green Labware: Nein
• Verpackungseinheit: 50 mg
• Mengeneinheit: STK