Octyl-α-ketoglutarate, CAS 876150-14-0

Formulation: A solution in methyl acetate

Formal Name: 2-oxo-pentanedioic acid, 1-octyl ester

Purity: ≥95%

Formula Markup: C13H22O5

Formula Weight: 258,3

Shelf life (days): 365

CAS Number: 876150-14-0

Notes: Hypoxia-inducible factor 1α (HIF-1α) turnover is initiated by prolyl hydroxylases (PHD), which hydroxylate proline residues on HIF-1α, facilitating ubiquitination. PHD activity is linked to the tricarboxylic acid (TCA) cycle, since the intermediate α-ketoglutarate is a PHD substrate and succinate and fumarate inhibit PHD. Mutations in enzymes associated with the TCA cycle occur in certain cancers.{21411} Octyl-α-ketoglutarate is a stable, cell-permeable form of α-ketoglutarate which accumulates rapidly and preferentially in cells with a dysfunctional TCA cycle.{21289} When used at 1 mM, it stimulates PHD activity, increasing HIF-1α turnover.{21289,21410} In addition, octyl-α-ketoglutarate competitively blocks succinate- or fumarate-mediated inhibition of PHD.{21289}

• Artikelnummer: CAY11970-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11970-25
• Green Labware: Nein
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK