Oleic Acid-d17, CAS 223487-44-3

Formulation: A solution in methyl acetate

Formal Name: 9Z-octadecenoic-11,11,12,12,13,13,14,14,15,15,16,16,17,17,18,18,18-d17 acid

Purity: ≥99% deuterated forms (d1-d17)

Formula Markup: C18H17D17O2

Formula Weight: 299,6

Shelf life (days): 730

CAS Number: 223487-44-3

Notes: Oleic acid-d17 is intended for use as an internal standard for the quantification of oleic acid (Item No. 90260) by GC- or LC-MS. Oleic acid is a monounsaturated fatty acid and a major component of membrane phospholipids that has been found in human plasma, cell membranes, and adipose tissue.{3964,42296} It contributes approximately 17% of the total fatty acids esterified to phosphatidylcholine, the major phospholipid class in porcine platelets.{3964} Oleic acid inhibits collagen-stimulated platelet aggregation by approximately 90% when used at a concentration of 10 µg/ml. It also inhibits fMLF-induced neutrophil aggregation and degranulation by 55 and 68%, respectively, when used at a concentration of 5 µM, similar to arachidonic acid (Item No. 90010 / 90010.1 / 10006607).{2095} Oleic acid (60 µM) induces release of intracellular calcium in human platelets.{4198} In vivo, oleic acid increases TNF-α, IL-8, IL-6, and IL-1β production, neutrophil accumulation, and apoptotic and necrotic cell death in mouse lung and has been used to induce lung injury in a mouse model of acute respiratory distress syndrome (ARDS).{42296}

• Artikelnummer: CAY9000432-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9000432-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung