Formulation: A solid
Formal Name: (R)-3-carboxy-N,N-dimethyl-N-(methyl-d3)-2-(oleoyloxy)propan-1-aminium, monochloride
Purity: ≥99% deuterated forms (d1-d3)
Formula Markup: C25H45D3NO4 • Cl
Formula Weight: 465,1
Shelf life (days): 730
Notes: Oleoyl-L-carnitine-d3 is intended for use as an internal standard for the quantification of oleoyl-L-carnitine (Item Nos. 26557 / 39014) by GC- or LC-MS. Oleoyl-L-carnitine is a long-chain acylcarnitine and an inhibitor of glycine transporter 2 (GlyT2; IC50 = 340 nM).{65783,65784} It is selective for GlyT2 over GlyT1 (IC50 = >10,000 nM). Plasma levels of oleoyl-L-carnitine are increased in patients with chronic kidney disease or end-stage renal disease receiving incident hemodialysis and these are associated with cardiovascular mortality.{65783}