Oleoyl Serinol, CAS 72809-08-6

Formulation: A crystalline solid

Formal Name: N-[2-hydroxy-1-(hydroxymethyl)ethyl]-9Z-octadecenamide

Purity: ≥98%

Formula Markup: C21H41NO3

Formula Weight: 355,6

Shelf life (days): 730

CAS Number: 72809-08-6

Notes: Oleoyl serinol is an analog of ceramide and an agonist of the cannabinoid receptor GPR119 that has an EC50 value of 12 µM for stimulating secretion of GLP-1 in mouse endocrine GLUTag cells.{39726} It has been found in E. coli that express human microbiota N-acyl synthase (hmNAS) genes. It induces cell death of F-11 murine neuroblastoma and apoptosis in U-87 human astrocytoma cells when used at a concentration of 100 µM.{10417} Oleoyl serinol (80 µM) induces formation of a complex including PAR-4 and PKCζ in embryoid body-derived cells, decreases the levels of the pluripotency marker Oct-4 and prostate apoptosis response-4 (PAR-4), which mediates ceramide-induced apoptosis in embryonic stem cells.{39727} It induces apoptosis selectively in rapidly dividing cells over differentiated cells as well as prevents teratoma formation and promotes neural differentiation in a neonatal mouse engraftment model of teratoma formation.

• Artikelnummer: CAY13637-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 13637-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK