Oroxylin A, CAS 480-11-5

Formulation: A solid

Formal Name: 5,7-dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one

Purity: ≥98%

Formula Markup: C16H12O5

Formula Weight: 284,3

Shelf life (days): 1460

CAS Number: 480-11-5

Notes: Oroxylin A is a flavonoid that has been found in S. radix and has diverse biological activities.{47464,47465,47466} It inhibits decreases in cell viability and increases in nitric oxide (NO) production induced by polyinosinic-polycytidylic acid (poly(I:C)) in RAW 264.7 macrophages when used at concentrations ranging from 5 to 25 μM.{47465} Oroxylin A (10-50 μM) also inhibits poly(I:C)-induced increases in IL-1α, IL-1β, GM-CSF, IL-6, IL-10, monocyte chemoattractant protein-1 (MCP-1), and TNF-α production in RAW 264.7 cells. Oroxylin A (10 and 20 μM) inhibits hypoxia-induced migration and invasion of MCF-7, DU145, and HepG2 cells in wound healing and cell invasion assays, respectively.{47466} It is an inhibitor of the UDP-glucuronosyltransferase (UGT) isoform UGT1A1 (IC50 = 9.14 μM) and P-glycoprotein (IC50 = 78.3 μM).{47467,47468} Oroxylin A increases the cytotoxicity of the P-glycoprotein substrate paraquat in MDR1-MDCKII cells and paclitaxel (Item No. 10461) in MX-1 and MX-1/T cells.{47468}

• Artikelnummer: CAY27363-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27363-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK