Prostaglandin D2 Ethanolamide, CAS 398138-28-8

Formulation: A solution in ethanol

Formal Name: N-(2-hydroxyethyl)-11-oxo-9α,15S-dihydroxy-prosta-5Z,13E-dien-1-amide

Purity: ≥96%

Formula Markup: C22H37NO5

Formula Weight: 395,5

Shelf life (days): 365

CAS Number: 398138-28-8

Notes: Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase.{11045,22752,22753} The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase.{12142} PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor.{12144} It increases the frequency of miniature inhibitory postsynaptic currents in primary cultured hippocampal neurons, an effect which is the opposite of that induced by anandamide.{22753}. PGD2-EA also induces apoptosis in colorectal carcinoma cell lines.{22752}

• Artikelnummer: CAY12012-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 12012-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK