Prostaglandin E2-d4-1-glyceryl ester

Formulation: A solution in acetonitrile

Formal Name: 9-oxo-11α,15S-dihydroxy-prosta-5Z,13E-dien-1-oic-2,2,3,3-d4 acid, 1-glycerol ester

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C23H34D4O7

Formula Weight: 430,6

Shelf life (days): 365

Notes: Prostaglandin E2-d4-1-glyceryl ester (PGE2-d4-1-glyceryl ester) is intended for use as an internal standard for the quantification of PGE2-1-glyceryl ester (Item No. 10140) by GC- or LC-MS. 2-Arachidonoyl glycerol (2-AG) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the CB1 receptor.{4614,5306} Incubation of 2-AG with COX-2 and specific prostaglandin H2 (PGH2) isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glycerol ester formation.{11045} The biosynthesis of PGH, PGD, PGE, PGF, and TXA-2-glyceryl ester compounds have all been documented. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media. While the stability and metabolism of these prostaglandin products has been investigated, little is known about their intrinsic biological activity.{10555}

• Artikelnummer: CAY14029-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 14029-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung