Prostaglandin E2 Ethanolamide, CAS 194935-38-1

Formulation: A crystalline solid

Formal Name: N-(2-hydroxyethyl)-9-oxo-11α,15S-dihydroxy-prosta-5Z,13E-dien-1-amide

Purity: ≥98%

Formula Markup: C22H37NO5

Formula Weight: 395,5

Shelf life (days): 365

CAS Number: 194935-38-1

Notes: Prostaglandin E2 ethanolamide (PGE2-EA) is an analog of PGE2 (Item No. 14010) with improved water solubility and stability. PGE2-EA is formed via COX-2 metabolism of arachidonoyl ethanolamide (AEA; Item No. 90050) and acts as an agonist at E prostanoid (EP) receptors 1-4 (Kis = 2.45, 0.46, 0.2, and 0.51 μM, respectively).{11045,10926} It also inhibits indoleamine 2,3-dioxygenase-1 (IDO-1) in THP-1 cells and human monocytes (IC50s = 5.7 and 4.7 μM, respectively).{40333} PGE2-EA (10 μM) prevents morphological changes and F-actin rearrangement as well as reduces L-homocysteine-induced NLRP3 inflammasome formation and activation in podocytes.{41626} Ex vivo, PGE2-EA reduces luminal damage and lymphocyte infiltration in a human mucosal explant colitis model.{41627}

• Artikelnummer: CAY14012-500
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 14012-500
• Green Labware: Nein
• Verpackungseinheit: 500 µg
• Mengeneinheit: STK