PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl)-d62 (sodium salt)

Formulation: A lyophilized powder

Formal Name: 1-(1,2R-dihexadecanoyl (2,2’,3,3’,4,4’,5,5’,6,6’,7,7’,8,8’,9,9’,10,10’,11,11’,12,12’,13,13’,14,14’,15,16,16,16-d62)phosphatidyl)inositol-3,4,5-trisphosphate, tetrasodium salt

Purity: ≥99% deuterated forms (d1-d62)

Formula Markup: C41H16D62O22P4 • 4Na

Formula Weight: 1201,3

Shelf life (days): 1825

Notes: PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl)-d62 (sodium salt) is intended for use as an internal standard for the quantification of PtdIns-(3,4,5)-P3 (1,2-dipalmitoyl) (sodium salt) (Item No. 64920) by GC- or LC-MS.. The phosphatidylinositol phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.{243,8344} PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and the Akt-family of GTPase activating proteins are examples of PtdIns-(3,4,5)-P3-binding proteins.{5241,8674} Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific phospholipase C (PLC). Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see references {3239} and {8672}.

• Artikelnummer: CAY9000414-50
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9000414-50
• Green Labware: Nein
• Verpackungseinheit: 50 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung