PtdIns-(3,4,5)-P3 (1-stearoyl, 2-arachidonoyl) (sodium salt)

Formulation: A lyophilized powder

Formal Name: 1-(1-octadecanoyl-2R-(5Z,8Z,11Z,14Z)-eicosatetraenoylphosphatidyl)inositol-3,4,5-trisphosphate, tetrasodium salt

Purity: ≥98%

Formula Markup: C47H82O22P4 • 4Na

Formula Weight: 1215

Shelf life (days): 1825

Notes: The phosphatidylinositol (PtdIns) phosphates represent a small percentage of total membrane phospholipids. However, they play a critical role in the generation and transmission of cellular signals.{243,8344} PtdIns-(3,4,5)-P3 can serve as an anchor for the binding of signal transduction proteins bearing pleckstrin homology (PH) domains. Centuarin α and Akts are examples of PtdIns-(3,4,5)-P3-binding proteins.{5241,8674} Protein-binding to PtdIns-(3,4,5)-P3 is important for cytoskeletal rearrangements and membrane trafficking. PtdIns-(3,4,5)-P3 is resistant to cleavage by PI-specific PLC. Thus, it is likely to function in signal transduction as a modulator in its own right, rather than as a source of inositol tetraphosphates. For further reading on inositol phospholipids, see also references {3239} and {8672}.

• Artikelnummer: CAY64930-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 64930-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK