(R)-(+)-Linoleyl-1'-Hydroxy-2'-Propylamide, CAS 220556-74-1

Formulation: A solution in ethanol

Formal Name: N-[(1R)-2-hydroxy-1-methylethyl]-9Z,12Z-octadecadienamide

Purity: ≥98%

Formula Markup: C21H39NO2

Formula Weight: 337,5

Shelf life (days): 365

CAS Number: 220556-74-1

Notes: N-Acyl ethanolamines have diverse biological actions that are strongly affected by the associated acyl group. Linoleoyl ethanolamide (LOEA) has potential signaling roles in aging and neurological functioning.{19623,11177} LOEA has a weak affinity for cannabinoid (CB) receptors (Ki = 10, 25 μM for CB1, CB2, respectively). {7422} Although hydrolized by fatty acid amide hydrolase (FAAH; Ki = 9 μM) it also inhibits FAAH and inhibits voltage-gated K+ channels.{7422,7251,3922,13859} (R)-(+)-Linoleyl-1’-hydroxy-2’-propylamide is a homolog of LOEA, characterized by the addition of an (R)-α-methyl group at the methylene carbon adjacent to the amide nitrogen. A similar modification of arachidonoyl ethanolamide (Item No. 90050) to produce R-1 methanandamide (Item No. 90070) imparts higher affinity for the CB receptor as well as improved metabolic stability.{1092} The physiological actions of this compound have not been evaluated.

• Artikelnummer: CAY9001233-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9001233-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK