(R)-(-)-Linoleyl-2'-Hydroxy-1'-Propylamide

Formulation: A solution in ethanol

Formal Name: N-((R)-2-hydroxypropyl)octadeca-9Z,12Z-dienamide

Purity: ≥98%

Formula Markup: C21H39NO2

Formula Weight: 337,5

Shelf life (days): 365

Notes: N-Acyl ethanolamines (NAEs) have diverse biological actions that are strongly affected by the associated acyl group. Linoleoyl ethanolamide (LOEA) has potential signaling roles in aging and neurological functioning.{19623,11177} LOEA has a weak affinity for cannabinoid (CB) receptors (Ki = 10, 25 μM for CB1, CB2, respectively) and inhibits voltage-gated K+ channels.{7422,13859} LOEA also inhibits fatty acid amide hydrolase (FAAH; Ki = 9 μM) and is hydrolyzed by FAAH.{7251,3922} (R)-(−)-Linoleyl-2’-hydroxy-1’-propylamide is a homolog of LOEA which is characterized by the addition of an (R)-β-methyl group at the terminal ethanolamine carbon. A similar modification of arachidonoyl ethanolamide (Item No. 90050) to produce R-2 methanandamide (Item No. 90074) imparts diminished affinity for the CB receptor as well as reduced metabolic stability.{1092} The physiological actions of this compound have not been evaluated.

• Artikelnummer: CAY9001234-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 9001234-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK