Resolvin D1, CAS 872993-05-0

Formulation: A solution in ethanol

Formal Name: 7S,8R,17S-trihydroxy-4Z,9E,11E,13Z,15E,19Z-docosahexaenoic acid

Purity: ≥95%

Formula Markup: C22H32O5

Formula Weight: 376,5

Shelf life (days): 365

CAS Number: 872993-05-0

Notes: Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310).{13989} In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.{14973} Resolvin D1 (RvD1) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase.{13989} A 17(R)-epimer (Item No. 13060) of RvD1 can also be generated in aspirin-treated samples.{11433} Both RvD1 and its 17(R)-configuration reduce human polymorphonuclear leukocyte (PMNL) transendothelial migration, the earliest event in acute inflammation, with EC50 values of ~30 nM.{15718} RvD1 and its aspirin-triggered form also exhibit a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with a maximal inhibition of ~35% at a 10-100 ng dose.{15718}

• Artikelnummer: CAY10012554-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10012554-10
• Green Labware: Nein
• Verpackungseinheit: 10 µg
• Mengeneinheit: STK