Resolvin D2-d5, CAS 1881277-33-3

Formulation: A solution in ethanol

Formal Name: 7S,16R,17S-trihydroxy-4Z,8E,10Z,12E,14E,19Z-21,21’,22,22,22-d5 docosahexaenoic acid

Purity: ≥99% deuterated forms (d1-d5)

Formula Markup: C22H27D5O5

Formula Weight: 381,5

Shelf life (days): 365

CAS Number: 1881277-33-3

Notes: Resolvin D2-d5 (RvD2-d5) is intended for use as an internal standard for the quantification of resolvin D2 (Item No. 10007279) by GC- or LC-MS. Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA).{13989} In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state.{14973} Resolvin D2 is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase and functions to dampen excessive neutrophil trafficking to sites of inflammation.{18209} It reduces zymosan-stimulated PMN infiltration by 70% at doses as low as 10 pg per mouse and significantly reduces PAF-stimulated leukocyte adherence and emigration at 1 nM.{18209} Also, by stimulating nitric oxide production, resolvin D2 dose dependently decreases leukocyte-endothelial interactions. In a murine model of sepsis, resolvin D2 reduces leukocyte and PMN infiltration, decreases production of pro-inflammatory cytokines, and promotes phagocyte-mediated bacterial clearance.{18209}

• Artikelnummer: CAY11184-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 11184-25
• Green Labware: Nein
• Verpackungseinheit: 25 µg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung