Resolvin E2, CAS 865532-70-3

Formulation: A solution in ethanol

Formal Name: 5S,18R-dihydroxy-6E,8Z,11Z,14Z,16E-eicosapentaenoic acid

Purity: ≥95%

Formula Markup: C20H30O4

Formula Weight: 334,5

Shelf life (days): 365

CAS Number: 865532-70-3

Notes: Resolvin E2 (RvE2) is a member of the specialized pro-resolving mediator (SPM) family of bioactive lipids.{58454} It is produced from eicosapentaenoic acid (EPA; Item Nos. 90110 / 90110.1 / 21908) via an 18-HEPE intermediate, which is formed by aspirin-acetylated COX-2-mediated oxidation of EPA, by 5-lipoxygenase (5-LO) in human polymorphonuclear (PMN) neutrophils.{14537,58455} RvE2 (20 ng/animal) inhibits increases in inflammatory exudate neutrophil infiltration in a mouse model of peritonitis induced by zymosan A (Item No. 21175).{58455} Hepatic RvE2 levels are increased in mice fed normal chow, as well as in a mouse model of high-fat diet-induced non-alcoholic fatty liver disease (NAFLD), by dietary supplementation with EPA.{58456} Plasma levels of RvE2 are increased by dietary supplementation with fish oil containing ω-3 polyunsaturated fatty acids (PUFAs) in patients with peripheral artery disease or chronic kidney disease.{58454,58457,58458}

• Artikelnummer: CAY13827-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 13827-10
• Green Labware: Nein
• Verpackungseinheit: 10 µg
• Mengeneinheit: STK