Rhein, CAS 478-43-3

Formulation: A crystalline solid

Formal Name: 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid

Purity: ≥95%

Formula Markup: C15H8O6

Formula Weight: 284,2

Shelf life (days): 1460

CAS Number: 478-43-3

Notes: Rhein is an anthraquinone derivative that has been found in R. rhabarbarum and a metabolite of diacerein (Item No. 11710) that has diverse biological activities, including anticancer, antioxidant, and anti-inflammatory activities.{46597,28413,46596,28415} It induces cell cycle arrest at the S phase and inhibits the proliferation of HepG2 cells when used at concentrations of 40 and 100 µM, respectively.{46597} Rhein (100 and 200 µM) also inhibits proliferation of MCF-7 and MDA-MB-435s breast cancer cells under normoxic and hypoxic conditions.{28413} It reduces controlled cortical impact-induced decreases in catalase and superoxide dismutase (SOD) activity and malondialdehyde (MDA), glutathione, and glutathione disulfide levels in the brain in a rat model of traumatic brain injury when administered at a dose of 12 mg/kg.{46596} Rhein (50 mg/kg per day) reduces increased serum TNF-α, IL-1β, and amylase levels, as well as reduces pancreatic glandular atrophy and fibrosis, in a mouse model of chronic pancreatitis induced by cerulein.{28415}

• Artikelnummer: CAY17345-250
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 17345-250
• Green Labware: Nein
• Verpackungseinheit: 250 mg
• Mengeneinheit: STK