Rotenone, CAS 83-79-4

Formulation: A crystalline solid

Formal Name: (2R,6aS,12aS)-1,2,12,12a-tetrahydro-8,9-dimethoxy-2-(1-methylethenyl)-[1]benzopyrano[3,4-b]furo[2,3-h][1]benzopyran-6(6aH)-one

Purity: ≥95%

Formula Markup: C23H22O6

Formula Weight: 394,4

Shelf life (days): 1460

CAS Number: 83-79-4

Notes: Rotenone is a classical inhibitor of complex I of the mitochondrial electron transport chain, inhibiting NADH/DB oxidoreductase and NADH oxidase with IC50 values of 28.8 and 5.1 nM, respectively.{25505} In substantia nigra pars compacta neurons, it activates ATP-sensitive potassium channels and increases the production of reactive oxygen species (ROS) in the mitochondria, effects that are decreased by the antioxidant trolox (Item No. 10011659).{25508} In rodents, rotenone induces dopaminergic cell death in the substantia nigra, formation of cytoplasmic inclusions similar to Lewy bodies, oxidative damage to proteins, and parkinsonian symptoms of bradykinesia and rigidity.{25506} In a rat model of Parkinson’s disease, chronic rotenone administration of 1.5 and 2.5 mg/kg per day for two months reduces tyrosine hydroxylase levels in the posterior striatum and prefrontal cortex, induces catalepsy, and decreases spontaneous locomotion and exploration in the open field test.{41910} Formulations containing rotenone have been used as insecticides and piscicides.{25504}

• Artikelnummer: CAY13995-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 13995-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK