Safingol, CAS 15639-50-6

Formulation: A crystalline solid

Formal Name: (2S,3S)-2-amino1,3-octadecanediol

Purity: ≥98%

Formula Markup: C18H39NO2

Formula Weight: 301,5

Shelf life (days): 1460

CAS Number: 15639-50-6

Notes: Safingol is the L-threo diastereomer of D-erythro-sphinganine (Item No. 10007945) and a dual inhibitor of PKC and sphingosine kinase (SPHK).{30406,24886} It inhibits PKC by binding at the regulatory phorbol-binding domain (IC50 = 24 µM).{30406} Safingol also inhibits SPHK (Ki = ~5 µM).{24886} Safingol (0.2-6 µM) restores sensitivity to cisplatin (Item No. 13119) in resistant AGScis5 cells and N87 gastric cancer cells in a concentration-dependent manner.{30405} [Matreya, LLC. Catalog No. 1807]

• Artikelnummer: CAY18624-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 18624-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK