Formulation: A crystalline solid
Formal Name: (2S,3S)-2-amino1,3-octadecanediol
Purity: ≥98%
Formula Markup: C18H39NO2
Formula Weight: 301,5
Shelf life (days): 1460
CAS Number: 15639-50-6
Notes: Safingol is the L-threo diastereomer of D-erythro-sphinganine (Item No. 10007945) and a dual inhibitor of PKC and sphingosine kinase (SPHK).{30406,24886} It inhibits PKC by binding at the regulatory phorbol-binding domain (IC50 = 24 µM).{30406} Safingol also inhibits SPHK (Ki = ~5 µM).{24886} Safingol (0.2-6 µM) restores sensitivity to cisplatin (Item No. 13119) in resistant AGScis5 cells and N87 gastric cancer cells in a concentration-dependent manner.{30405} [Matreya, LLC. Catalog No. 1807]