Sciadopitysin, CAS 521-34-6

Formulation: A solid

Formal Name: 5,7-dihydroxy-8-[5-(5-hydroxy-7-methoxy-4-oxo-4H-1-benzopyran-2-yl)-2-methoxyphenyl]-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one

Purity: ≥98%

Formula Markup: C33H24O10

Formula Weight: 580,5

Shelf life (days): 1460

CAS Number: 521-34-6

Notes: Sciadopitysin is a biflavonoid originally isolated from G. biloba and has diverse biological activities.{42865,42866,42867,42868} It reduces cytotoxicity induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in PC12 cells (EC50 = 9.84 μM).{42866} Sciadopitysin (0.1-10 μM) decreases methylglyoxal-induced insulin secretion, production of reactive oxygen species (ROS), cardiolipin peroxidation, and cytotoxicity in RIN-m5F pancreatic β-cells.{42867} It inhibits P-glycoprotein (P-gp; IC50 = 53.42 μM) and increases cellular toxicity of paraquat and paclitaxel (Item No. 10461) in MDR1-MDCKII cells.{47468} Sciadopitysin inhibits RANKL-induced mRNA expression of the osteoclast-specific genes CTSK, TRAP, and MMP-9, activation of NF-κB, and osteoclastogenesis in a mouse model of LPS-induced bone loss.{42868}

• Artikelnummer: CAY27900-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 27900-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK