Thioetheramide-PC, CAS 116457-99-9

Formulation: A solution in ethanol

Formal Name: 1,2-dideoxy-1-(S-hexadecyl)thio-2-(N-hexadecanoyl)amino-sn-glyceryl-3-phosphorylcholine

Purity: ≥95%

Formula Markup: C40H83N2O5PS

Formula Weight: 735,1

Shelf life (days): 365

CAS Number: 116457-99-9

Notes: Thioetheramide-PC is a structurally modified phospholipid that functions as a competitive, reversible inhibitor of secretory phospholipase A2 (sPLA2).{808,2624} The IC50 value for thioetheramide-PC is 2 µM at a substrate concentration of 0.5 mM.{808} In addition to binding to the catalytic site of sPLA2, thioetheramide-PC also binds to the activator site of this enzyme. The binding of thioetheramide-PC to the activator site is tighter than its binding to the catalytic site. The result of this dual interaction is that at low concentrations thioetheramide-PC may activate phospholipase activity rather than inhibiting it.{808}

• Artikelnummer: CAY62750-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 62750-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK