Tumulosic Acid, CAS 508-24-7

Formulation: A solid

Formal Name: (3β,16α)-3,16-dihydroxy-24-methylene-lanost-8-en-21-oic acid

Purity: ≥98%

Formula Markup: C31H50O4

Formula Weight: 486,7

Shelf life (days): 1460

CAS Number: 508-24-7

Notes: Tumulosic acid is a triterpene that has been found in Poria cocos and has diverse biological activities.{47969,47970,47971,47972} It inhibits DNA topoisomerase I and II by 83.3 and 75.5%, respectively, when used at a concentration of 100 µM.{47969} Tumulosic acid also inhibits kallikrein 5 and trypsin but not kallikrein 7 or chymotrypsin C (IC50s = 14.8, 45.3, >100, and >100 µM for the human enzymes, respectively).{47970} It inhibits LPS-induced nitric oxide (NO) production (IC50 = 42.5 µM) and activator protein 1 (AP-1) transcriptional activity in RAW 264.7 macrophages.{47971} Tumulosic acid (30 µg/ear) reduces ear edema induced by phorbol 12-myristate 13-acetate (TPA; Item No. 10008014) in mice.{47972}

• Artikelnummer: CAY36021-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36021-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe