Ursodeoxycholic Acid MaxSpec® Standard, CAS 128-13-2

Formulation: A solution in methanol at 100 µg/ml (nominal); see CofA for verified concentration

Formal Name: (3α,5β,7β)-3,7-dihydroxy-cholan-24-oic acid

Purity: ≥95%

Formula Markup: C24H40O4

Formula Weight: 392,6

Shelf life (days): 1825

CAS Number: 128-13-2

Notes: Ursodeoxycholic acid (UDCA) is a secondary bile acid formed via epimerization of chenodeoxycholic acid (CDCA; Item No. 10011286).{48224,48225} UDCA is also a metabolite of lithocholic acid (LCA; Item No. 20253) in human liver microsomes.{48226} It inhibits taurocholic acid (Item No. 16215) uptake in HeLa cells expressing recombinant sodium/taurocholate cotransporting polypeptide (NTCP) with an IC50 value of 3.6 μM.{24182} UDCA (50 μM) inhibits apoptosis induced by deoxycholic acid (DCA; Item Nos. 20756 / 18231) or ethanol in primary rat hepatocytes.{48227} Dietary administration of UDCA blocks DCA-induced increases in the number of TUNEL-positive hepatocytes in rats. Formulations containing UDCA have been used in the treatment of primary biliary cirrhosis. UDCA MaxSpec® standard is a quantitative grade standard of UDCA (Item No. 15121) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. The verified concentration is provided on the certificate of analysis. This UDCA MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

• Artikelnummer: CAY31367
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 31367-100
• Green Labware: Nein
• Verpackungseinheit: 100 µg
• Mengeneinheit: STK
• Methode: Reinstoffe, Isotopenmarkierung