Wogonoside, CAS 51059-44-0

Formulation: A solid

Formal Name: 5-hydroxy-8-methoxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl β-D-glucopyranosiduronic acid

Purity: ≥98%

Formula Markup: C22H20O11

Formula Weight: 460,4

Shelf life (days): 1460

CAS Number: 51059-44-0

Notes: Wogonoside is an active metabolite of wogonin (Item No. 14248) and a flavonoid that has been found in S. baicalensis and has anti-inflammatory and anticancer activities.{49413,49419,49420} It decreases the levels of IL-1β, TNF-α, and IL-6 and inhibits the activation of NF-κB and the NOD-, LRR-, and pyrin domain-containing protein 3 (NLRP3) inflammasome in THP-1 cells differentiated with phorbol 12-myristate 13-acetate (PMA; Item No. 10008014).{49413} Wogonoside (25 and 50 mg/kg) decreases colonic pathological damage and the activity of myeloperoxidase and inducible nitric oxide synthase (iNOS), as well as inhibits NF-κB and NLRP3 inflammasome activation in the colon in a mouse model of colitis induced by dextran sulfate sodium (Item No. 23250). It inhibits phosphorylation of the mammalian target of rapamycin (mTOR), as well as inhibits the growth of (IC50 = 133.9 µM), and induces autophagy in, MDA-MB-231 breast cancer cells.{49419} Wogonoside (50-100 µM) inhibits tube formation by human umbilical vein endothelial cells (HUVECs) and increases Wnt3a levels and β-catenin phosphorylation in MCF-7 cells and reduces tumor growth and angiogenesis in an MCF-7 mouse xenograft model when administered at a dose of 80 mg/kg.{49420}

• Artikelnummer: CAY29332-100
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29332-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK