Zearalanone, CAS 5975-78-0

Formulation: A crystalline solid

Formal Name: (3S)-3,4,5,6,9,10,11,12-octahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione

Purity: ≥98%

Formula Markup: C18H24O5

Formula Weight: 320,4

Shelf life (days): 1460

CAS Number: 5975-78-0

Notes: Zearalanone is a mycotoxin, an estrogen receptor (ER) agonist, and an active metabolite of α-zearalanol (Item No. 23424) and the mycotoxin zearalenone (Item No. 11353).{31432,31434} Zearalanone induces reporter gene expression in S. cerevisiae expressing human ER (EC50 = 110 nM).{31432} It is also an androgen receptor antagonist (IC50 = 1,540 nM for the human receptor).{31434} It induces delayed maturation of primary bovine oocytes when used at a concentration of 30 µg/ml.{66491} Zearalanone induces cytotoxicity in isolated phorbol 12-myristate 13-acetate-stimulated pig neutrophils (IC50 = 53.1 µM). It increases intracellular superoxide levels when used at a concentration of 1 µM, and decreases IL-8 supernatant levels in the same cells at 10 µM.{69470} Zearalanone has been found as a contaminant in harvested maize, sorghum, and wheat.{31430}

• Artikelnummer: CAY19459-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 19459-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK