Mastoparan X (trifluoroacetate salt), CAS 72093-22-2

Formulation: A solid

Formal Name: L-isoleucyl-L-asparaginyl-L-tryptophyl-L-lysylglycyl-L-isoleucyl-L-alanyl-L-alanyl-L-methionyl-L-alanyl-L-lysyl-L-lysyl-L-leucyl-L-leucinamide, trifluoroacetate salt

Purity: ≥98%

Formula Markup: C73H126N20O15S • XCF3COOH

Formula Weight: 1556

Shelf life (days): 1460

CAS Number: 72093-22-2

Notes: Mastoparan X is an antimicrobial peptide that has been found in wasp venom.{51375} It is active against several Gram-positive and Gram-negative bacteria (MICs = 3-64 and 4-256 µg/ml, respectively) and induces permeabilization of E. coli cytoplasmic membranes by 86% when used at a concentration of 6.4 µg/ml. Mastoparan X induces GDP/GTP exchange by Gi in a concentration-dependent manner and binds to calmodulin (Kd = ~0.9 nM) in cell-free assays.{33686,33682} It induces necrosis in T98G glioblastoma multiforme (GBM) cells when used at a concentration of 20 µM.{51376} Mastoparan X (128 µg/ml) induces degranulation of isolated rat peritoneal mast cells and hemolysis of isolated sheep, chicken, and human erythrocytes in a concentration-dependent manner.{51375} In vivo, mastoparan X (20 mg/kg) increases survival, decreases disease severity, and prevents damage to jejunal villi and crypts in a mouse model of enterohemorrhagic E. coli infection.{51377}

• Artikelnummer: CAY36903-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 36903-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK