Mebhydroline (1,5-naphthalenedisulfonate), CAS 6153-33-9

Formulation: A solid

Formal Name: 1,5-naphthalenedisulfonic acid, compd. with 2,3,4,5-tetrahydro-2-methyl-5-(phenylmethyl)-1H-pyrido[4,3-b]indole (1:2)

Purity: ≥98%

Formula Markup: C19H20N2 • 1/2C10H8O6S2

Formula Weight: 420,5

Shelf life (days): 1460

CAS Number: 6153-33-9

Notes: Mebhydroline is a histamine H1 receptor antagonist (Ki = 7.6 nM).{23214} It is selective for the histamine H1 receptor over muscarinic acetylcholine receptors (mAChRs; Ki = 180 nM). Mebhydroline (10 µM) inhibits acid sphingomyelinase in H4 neuroglioma cells and binds to the ligand-binding domain of the farnesoid X receptor (FXR; Kd = 9.87 µM).{26583,72266} It inhibits transactivation of FXR induced by the FXR agonist GW 4064 (Item No. 10006611) in HEK293T cells expressing the human receptor in a concentration-dependent manner.{72266} Mebhydroline binds to Zika virus RNA-dependent RNA polymerase (RdRp; Kd = 22.62 µM) and reduces viral replication in Zika-infected Vero cells (EC50 = 5.14 µM).{72267} In vivo, mebhydroline (30 mg/kg) decreases blood glucose and plasma hemoglobin A1c (HbA1c) levels in db/db diabetic mice.{72266}

• Artikelnummer: CAY40281-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 40281-10
• Verpackungseinheit: 10 g
• Mengeneinheit: STK