Formulation: A solid
Formal Name: 1-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]-1H-benzotriazole, monohydrochloride
Purity: ≥98%
Formula Markup: C21H24N6S • HCl
Formula Weight: 429
Shelf life (days): 730
CAS Number: 1610794-70-1
Notes: MT-1207 is an antagonist of α1A-, α1B-, and α1D-adrenergic receptors and the serotonin (5-HT) receptor subtype 5-HT2A (IC50s = 1A, 5-HT1B, 5-HT2B, and 5-HT2C receptors (IC50s = 18.1, 4.89, 4.68, 41, 11.5, and 26 nM, respectively), among others. MT-1207 induces relaxation of isolated rat aortic rings precontracted with epinephrine, potassium chloride, norepinephrine, or 5-HT in a concentration-dependent manner. It decreases systolic and diastolic blood pressure and heart rate in spontaneously hypertensive rats and two kidney-one clip (2K-1C) renal hypertensive dogs when administered at doses of 10 and 4 mg/kg, respectively.
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