2-Hydroxychalcone, CAS 644-78-0

Product Description: 2-hydroxychalcone, a natural flavonoid, is a potent antioxidant, inhibiting lipid peroxidation. 2-Hydroxychalcone induces apoptosis by Bcl-2 downregulation. 2-Hydroxychalcone inhibits the activation of NF-kB[1][2][3].

Applications: Metabolism-sugar/lipid metabolism

Formula: C15H12O2

References: [1]Sun Young Kim, et al. 2-Hydroxychalcone and Xanthohumol Inhibit Invasion of Triple Negative Breast Cancer Cells. Chem Biol Interact. 2013 May 25;203(3):565-72./[2]B Madan, et al. 2'-hydroxychalcone Inhibits Nuclear factor-kappaB and Blocks Tumor Necrosis Factor-Alpha- And Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol. 2000 Sep;58(3):526-34./[3]BABITA MADAN, et al. 2-Hydroxychalcone Inhibits Nuclear Factor-kB and Blocks Tumor Necrosis Factor-a- and Lipopolysaccharide-Induced Adhesion of Neutrophils to Human Umbilical Vein Endothelial Cells. Mol Pharmacol 58:526–534, 2000.

CAS Number: 644-78-0

Molecular Weight: 224.25

Compound Purity: 98.80

Research Area: Cancer; Metabolic Disease

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: Apoptosis;Bcl-2 Family;NF-κB;Parasite

• Artikelnummer: MEXHY-119931-500
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-119931-500
• Green Labware: Nein
• Verpackungseinheit: 500 mg
• Mengeneinheit: STK