20(R)-Ginsenoside Rh2, CAS 112246-15-8

Product Description: 20(R)-Ginsenoside Rh2, a matrix metalloproteinase (MMP) inhibitor, acts as a cell antiproliferator. It has anticancer effects via blocking cell proliferation and causing G1 phase arrest. 20(R)-Ginsenoside Rh2 induces apoptosis, and has anti-inflammatory and antioxidative activity[1][2][3]. 20(R)-Ginsenoside Rh2 inhibits the replication and proliferation of mouse and human gammaherpesvirus 68 (MHV-68) with an IC50 of 2.77 μM for murine MHV-68[4].

Applications: Cancer-Kinase/protease

Formula: C36H62O8

References: [1]Choi WY, et al. Anti-inflammatory, antioxidative and matrix metalloproteinase inhibitory properties of 20(R)-ginsenoside Rh2 in cultured macrophages and keratinocytes. J Pharm Pharmacol. 2013 Feb;65(2):310-6./[2]Chung KS, et al. Ginsenoside Rh2 induces cell cycle arrest and differentiation in human leukemia cells by upregulating TGF-β expression. Carcinogenesis. 2013 Feb;34(2):331-40./[3]Choi S, et al. Ginsenoside Rh2-mediated G1 phase cell cycle arrest in human breast cancer cells is caused by p15 Ink4B and p27 Kip1-dependent inhibition of cyclin-dependent kinases. Pharm Res. 2009 Oct;26(10):2280-8./[4]Kang S, et al. Antiviral activity of 20(R)-ginsenoside Rh2 against murine gammaherpesvirus. J Ginseng Res. 2017 Oct;41(4):496-502.

CAS Number: 112246-15-8

Molecular Weight: 622.87

Compound Purity: 98.0

Research Area: Cancer; Infection; Inflammation/Immunology

Solubility: DMSO : 125 mg/mL (ultrasonic)

Target: Apoptosis;HSV;MMP

• Artikelnummer: MEXHY-N1401-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N1401-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK