3',4'-Dimethoxyflavone, CAS 4143-62-8

Product Description: 3',4'-Dimethoxyflavone is a lipophilic flavone, can be isolated from the leaves of Primula veris. 3',4'-Dimethoxyflavone can reduce the synthesis and accumulation of PARP and protect cortical neurones against cell death induced by Parthanatos. 3',4'-Dimethoxyflavone is also an aryl hydrocarbon receptor antagonist in human breast cancer cells. 3',4'-Dimethoxyflavone can promote the proliferation of human hematopoietic stem cells. 3',4'-Dimethoxyflavone has various biological activities, including antioxidant, anti-cancer, anti-inflammatory, anti-atherogenic, hypolipidaemic, and neuroprotective or neurotrophic effects[1][2][3][4].

Applications: COVID-19-anti-virus

Formula: C17H14O4

References: [1]Budzianowski J, et al. Lipophilic flavones of Primula veris L. from field cultivation and in vitro cultures. Phytochemistry. 2005 May;66(9):1033-9./[2]Lee JE, et al. 3',4'-dimethoxyflavone as an aryl hydrocarbon receptor antagonist in human breast cancer cells. Toxicol Sci. 2000 Dec;58(2):235-42./[3]Kaur K, et al. 3',4'-Dimethoxyflavone and valproic acid promotes the proliferation of human hematopoietic stem cells. Stem Cell Res Ther. 2013 May 24;4(3):60./[4]Fatokun AA, et al. Identification through high-throughput screening of 4'-methoxyflavone and 3',4'-dimethoxyflavone as novel neuroprotective inhibitors of parthanatos. Br J Pharmacol. 2013 Jul;169(6):1263-78.

CAS Number: 4143-62-8

Molecular Weight: 282.29

Compound Purity: 98.76

Research Area: Cancer; Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Solubility: DMSO : ≥ 50 mg/mL

Target: Aryl Hydrocarbon Receptor;PARP;Reactive Oxygen Species

• Artikelnummer: MEXHY-N8572-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N8572-10.1
• Green Labware: Nein
• Verpackungseinheit: 10mM/1mL
• Mengeneinheit: STK