3-Deoxyglucosone, CAS 4084-27-9

Product Description: 3-Deoxyglucosone (3-Deoxy-D-glucosone) is a reactive intermediate of the Maillard reaction and the polyol pathway. 3-Deoxyglucosone rapidly reacts with protein amino groups to form advanced glycation end products (AGEs), such as imidazolone, it is the most specific AGE for 3-DG. 3-Deoxyglucosone synergizes with low glucose to potentiate GLP-1 secretion and is considered as a biomarker for diabetes[1][2][3].

Applications: Metabolism-sugar/lipid metabolism

Formula: C6H10O5

References: [1]Song X, et al. 3-Deoxyglucosone Induces Glucagon-Like Peptide-1 Secretion from STC-1 Cells via Upregulating Sweet Taste Receptor Expression under Basal Conditions.Int J Endocrinol. 2019 Oct 23;2019:4959646./[2] Wang F, et al. Acute Reduction of Incretin Effect and Glucose Intolerance in Rats by Single Intragastric Administration of 3-deoxyglucosone. Exp Clin Endocrinol Diabetes. 2017 Jan;125(1):4-11./[3]Zhang L, et al. Accumulation of intestinal tissue 3-deoxyglucosone attenuated GLP-1 secretion and its insulinotropic effect in rats. Diabetol Metab Syndr. 2016 Nov 29;8:78./[4]Niwa T, et al. 3-Deoxyglucosone: metabolism, analysis, biological activity, and clinical implication.J Chromatogr B Biomed Sci Appl. 1999 Aug 6;731(1):23-36.

CAS Number: 4084-27-9

Molecular Weight: 162.14

Research Area: Metabolic Disease

Solubility: 10 mM in DMSO

Target: GLP Receptor

• Artikelnummer: MEXHY-N7426-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N7426-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK