3-Nitropropanoic acid, CAS 504-88-1

Product Description: 3-Nitropropanoic acid (β-Nitropropionic acid) is an irreversible and orally active inhibitor of succinate dehydrogenase. 3-Nitropropanoic acid exhibits potent antimycobacterial activity with a MIC value of 3.3 μM. 3-Nitropropanoic acid can induce cell apoptosis[1][2].

Applications: Metabolism-sugar/lipid metabolism

Formula: C3H5NO4

References: [1]Solesio ME, et al. 3-Nitropropionic acid induces autophagy by forming mitochondrial permeability transition pores rather than activating the mitochondrial fission pathway. Br J Pharmacol. 2013 Jan;168(1):63-75./[2]Kang B, et al. Effect of 3-nitropropionic acid inducing oxidative stress and apoptosis of granulosa cells in geese. Biosci Rep. 2018 Sep 12;38(5):BSR20180274./[3]Pang Z, Geddes JW. Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: acute excitotoxic necrosis and delayed apoptosis. J Neurosci. 1997 May 1;17(9):3064-73./[4]Túnez I, et al. Protective effect of melatonin on 3-nitropropionic acid-induced oxidative stress in synaptosomes in an animal model of Huntington's disease. J Pineal Res. 2004 Nov;37(4):252-6./[5]Urbanska EM, et al. A. Mitochondrial toxin 3-nitropropionic acid evokes seizures in mice. Eur J Pharmacol. 1998 Oct 16;359(1):55-8. /[6]Huang LS, et al. 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J Biol Chem. 2006 Mar 3;281(9):5965-72./[7]Chomcheon P, et al. 3-Nitropropionic acid (3-NPA), a potent antimycobacterial agent from endophytic fungi: is 3-NPA in some plants produced by endophytes? J Nat Prod. 2005 Jul;68(7):1103-5.

CAS Number: 504-88-1

Molecular Weight: 119.08

Compound Purity: 99.93

Research Area: Infection; Metabolic Disease

Solubility: DMSO : 125 mg/mL (ultrasonic)/H2O : 100 mg/mL (ultrasonic)

Target: Apoptosis;Autophagy;Bacterial

• Artikelnummer: MEXHY-W012875-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-W012875-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK