4,5-Dimethoxycanthin-6-one, CAS 18110-87-7

Product Description: 4,5-Dimethoxycanthin-6-one is a potent and uncompetitive inhibitor of CYP1A2-mediated phenacetin O-deethylation with an IC50 value of 1.7μM and a Ki value of 2.6 μM. 4,5-Dimethoxycanthin-6-one, as an alkaloid, is isolated from the wood of Picrasma quassioides BENNET (Simaroubaceae)[1][2].

Applications: Metabolism-sugar/lipid metabolism

Formula: C16H12N2O3

References: [1]Taichi O, et al. Studies on the Constituents of Picrasma quassioides BENNET. III. The Alkaloidal Constituents/[2]Miao X,et al. In vitro metabolism of 4, 5-dimethoxycanthin-6-one by human liver microsomes and its inhibition on human CYP1A2. Life Sci. 2017;190:46-51.

CAS Number: 18110-87-7

Molecular Weight: 280.28

Compound Purity: 98.68

Research Area: Metabolic Disease

Solubility: DMSO : 10 mg/mL (ultrasonic)

Target: Cytochrome P450

• Artikelnummer: MEXHY-N1882-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N1882-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK