4'-Hydroxychalcone, CAS 2657-25-2

Product Description: 4'-Hydroxychalcone is a chalcone isolated from licorice root, with hepatoprotective activity. 4'-Hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. 4'-Hydroxychalcone induces a rapid potassium release from mitochondrial vesicles and causes deterioration of respiratory control and oxidative phosphorylation of isolated rat liver mitochondria[1][2][3].

Applications: Cancer-Kinase/protease

Formula: C15H12O2

References: [1]Inoue B, et al. The effects of echinatin and its related compounds on the mitochondrial energy transfer reaction. J Toxicol Sci. 1982 Nov;7(4):245-54./[2]Ali Reza, et al. Hepatoprotective activity of phloretin and hydroxychalcones against Acetaminophen Induced hepatotoxicity in mice. Iranian Journal of Pharmaceutical Sciences. 2011 Jan; 7(2)./[3]Orlikova B, et al. The aromatic ketone 4'-hydroxychalcone inhibits TNFα-induced NF-κB activation via proteasome inhibition. Biochem Pharmacol. 2011 Sep 15;82(6):620-31.

CAS Number: 2657-25-2

Molecular Weight: 224.25

Compound Purity: 99.66

Research Area: Cancer; Inflammation/Immunology

Solubility: DMSO : 250 mg/mL (ultrasonic)

Target: Oxidative Phosphorylation;Proteasome

• Artikelnummer: MEXHY-N7056-5G
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N7056-5G
• Green Labware: Nein
• Verpackungseinheit: 5 g
• Mengeneinheit: STK