Product Description: 4-Hydroxyestrone (4-OHE1), an estrone metabolite, has strong neuroprotective effect against oxidative neurotoxicity. 4-Hydroxyestrone increases cytoplasmic translocation of p53 resulting from SIRT1-mediated deacetylation of p53. 4-Hydroxyestrone has little estrogenic activity[1].
Applications: Neuroscience-Neuromodulation
Formula: C18H22O3
References: [1]Hye Joung Choi, et al. 4-Hydroxyestrone, an Endogenous Estrogen Metabolite, Can Strongly Protect Neuronal Cells Against Oxidative Damage. Sci Rep. 2020 Apr 29;10(1):7283.
CAS Number: 3131-23-5
Molecular Weight: 286.37
Compound Purity: 99.0
Research Area: Neurological Disease
Solubility: 10 mM in DMSO
Target: Endogenous Metabolite