4-tert-Octylphenol, CAS 140-66-9

Product Description: 4-tert-Octylphenol, a endocrine-disrupting chemical, is an estrogenic agent. 4-tert-Octylphenol is also a biodegradation product of non-ionic surfactants alkylphenol polyethoxylates. 4-tert-Octylphenol induces apoptosis in neuronal progenitor cells in offspring mouse brain. 4-tert-Octylphenol reduces bromodeoxyuridine (BrdU), mitotic marker Ki67, and phospho-histone H3 (p-Histone-H3), resulting in a reduction of neuronal progenitor proliferation. 4-tert-Octylphenol disrupts brain development and behavior in mice, which is promising for reserch of immune response, neuro-related diseases and ethology[1][2][3][4].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C14H22O

References: [1]Dinh Nam Tran, et al. 4-tert-Octylphenol Exposure Disrupts Brain Development and Subsequent Motor, Cognition, Social, and Behavioral Functions. Oxidative Medicine and Cellular Longevity, 2020./[2]Olaniyan LWB, et al. Environmental Water Pollution, Endocrine Interference and Ecotoxicity of 4-tert-Octylphenol: A Review[J]. Rev Environ Contam Toxicol. 2020;248:81-109./[3]Maciuszek M, et al. 17α-ethinylestradiol and 4-tert-octylphenol concurrently disrupt the immune response of common carp[J]. Fish Shellfish Immunol. 2020 Dec;107(Pt A):238-250./[4]Lee J, Zee S, et al. Effects of crosstalk between steroid hormones mediated thyroid hormone in zebrafish exposed to 4-tert-octylphenol: Estrogenic and anti-androgenic effects[J]. Ecotoxicol Environ Saf. 2024 Jun 1;277:116348.

CAS Number: 140-66-9

Molecular Weight: 206.32

Compound Purity: 99.48

Research Area: Endocrinology; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Apoptosis;DNA/RNA Synthesis;Endogenous Metabolite

• Artikelnummer: MEXHY-B1941-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B1941-10.1
• Verpackungseinheit: 10mM/1mL
• Mengeneinheit: STK