Actein, CAS 18642-44-9

Product Description: Actein is a triterpene glycoside isolated from the rhizomes of Cimicifuga foetida. Actein suppresses cell proliferation, induces autophagy and apoptosis through promoting ROS/JNK activation, and blunting AKT pathway in human bladder cancer. Actein has little toxicity in vivo[1][2].

Applications: Cancer-Kinase/protease

Formula: C37H56O11

References: [1]Yang ZC, et al. Actein enhances TRAIL effects on suppressing gastric cancer progression by activating p53/Caspase-3 signaling. Biochem Biophys Res Commun. 2018 Mar 18;497(4):1177-1183./[2]Ji L, et al. Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways. Oncotarget. 2017 Nov 1;8(68):112498-112515.

CAS Number: 18642-44-9

Molecular Weight: 676.83

Compound Purity: 98.58

Research Area: Cancer

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Akt;Apoptosis;Autophagy;JNK

• Artikelnummer: MEXHY-N6872-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N6872-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK