Bergaptol, CAS 486-60-2

Product Description: Bergaptol is an inhibitor of debenzylation of the CYP3A4 enzyme with an IC50 of 24.92 μM. Recent studies have shown that it has anti-proliferative and anti-cancer properties[1].

Applications: Cancer-programmed cell death

Formula: C11H6O4

References: [1]Basavaraj Girennavar et al. Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Bioorganic & Medicinal Chemistry.June 2007, Pages 3684-3691/[2]Yucheng Zhao et al. Cloning, Functional Characterization, and Catalytic Mechanism of a Bergaptol O-Methyltransferase from Peucedanum praeruptorum Dunn. Front Plant Sci, 2016, 7: 722./[3]Shen CY, et al. Bergaptol from blossoms of Citrus aurantium L. var. amara Engl inhibits LPS-induced inflammatory responses and ox-LDL-induced lipid deposition. Food Funct. 2020 Jun 24;11(6):4915-4926./[4]Wu J, et al. Bergaptol Alleviates LPS-Induced Neuroinflammation, Neurological Damage and Cognitive Impairment via Regulating the JAK2/STAT3/p65 Pathway. J Inflamm Res. 2022 Nov 9;15:6199-6211.

CAS Number: 486-60-2

Molecular Weight: 202.16

Compound Purity: 99.44

Research Area: Cancer; Inflammation/Immunology; Neurological Disease

Solubility: DMSO : ≥ 50 mg/mL/H2O : < 0.1 mg/mL (ultrasonic)

Target: Cytochrome P450

• Artikelnummer: MEXHY-76316-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-76316-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK