Boldine, CAS 476-70-0

Product Description: Boldine is an apomorphine isoquinoline alkaloid extracted from the root of the pheasant pepper (Litsea cubeba). Boldine is an oral effective antioxidant, anti-inflammatory, antitumor agent, and can inhibit osteoclast formation. Boldine induces apoptosis of human bladder cancer cells by regulating ERK, AKT and GSK-3β. Boldine ameliorates bone destruction by down-regulating the OPG/RANKL/RANK signaling pathway. It can be used in rheumatoid arthritis research[1][2][3].

Applications: COVID-19-immunoregulation

Formula: C19H21NO4

References: [1]Zhao H , et al. Boldine isolated from <i>Litsea cubeba</i> inhibits bone resorption by suppressing the osteoclast differentiation in collagen-induced arthritis. Int Immunopharmacol. 2017 Oct;51:114-123./[2]Pandurangan AK, et al. Boldine suppresses dextran sulfate sodium-induced mouse experimental colitis: NF-κB and IL-6/STAT3 as potential targets. Biofactors. 2016 May;42(3):247-58./[3]Gerhardt D, et al. Boldine induces cell cycle arrest and apoptosis in T24 human bladder cancer cell line via regulation of ERK, AKT, and GSK-3β. Urol Oncol. 2014 Jan;32(1):36.e1-9.

CAS Number: 476-70-0

Molecular Weight: 327.37

Compound Purity: 99.57

Research Area: Inflammation/Immunology

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Apoptosis;RANKL/RANK

• Artikelnummer: MEXHY-N6973-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N6973-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK