Bonannione A, CAS 97126-57-3

Product Description: Bonannione A (6-Geranylnaringenin; Mimulone), a prenylflavonoid, is an orally active and potent protein tyrosine phosphatase 1B (PTP1B) inhibitor with an IC50 of 14 µM. Bonannione A triggers caspase-dependent apoptosis. Bonannione A induces autophagy through p53-mediated AMPK/mTOR pathway. Bonannione A shows anti-inflammatory, antiradical and anti-cancer activity[1][2][3].

Applications: COVID-19-immunoregulation

Formula: C25H28O5

References: [1]Lai-Bin Zhang, et al. Isoprenylated Flavonoids with PTP1B Inhibition from Macaranga denticulate. Nat Prod Bioprospect. 2016 Feb;6(1):25-30./[2]Hyun-Kyu An, et al. Mimulone-induced autophagy through p53-mediated AMPK/mTOR pathway increases caspase-mediated apoptotic cell death in A549 human lung cancer cells. PLoS One. 2014 Dec 9;9(12):e114607./[3]Zora Vochyánová, et al. Diplacone and mimulone ameliorate dextran sulfate sodium-induced colitis in rats. Fitoterapia. 2015 Mar;101:201-7.

CAS Number: 97126-57-3

Molecular Weight: 408.49

Research Area: Cancer; Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Apoptosis;Autophagy;Phosphatase

• Artikelnummer: MEXHY-124896-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-124896-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK