Catharanthine (Tartrate), CAS 4168-17-6

Product Description: Catharanthine ((+)-3,4-Didehydrocoronaridine) Tartrate, a constituent of anticancer vinca alkaloids, inhibits voltage-operated L-type Ca2+ channel (VOCC). Catharanthine Tartrate has IC50s of 220 μM and 8 μM for VOCC currents in cardiomyocytes and vascular smooth muscle cells (VSMCs), respectively. Catharanthine Tartrate lowers blood pressure (BP), heart rate (HR). Catharanthine Tartrate has anti-cancer activity[1][2].

Applications: Cancer-programmed cell death

Formula: C25H30N2O8

References: [1]Jadhav A, et al. Catharanthine dilates small mesenteric arteries and decreases heart rate and cardiac contractility by inhibition of voltage-operated calcium channels on vascular smooth muscle cells and cardiomyocytes. J Pharmacol Exp Ther. 2013 Jun;345(3):383-92./[2]Hugo R Arias, et al. (+)-Catharanthine and (-)-18-methoxycoronaridine induce antidepressant-like activity in mice by differently recruiting serotonergic and norepinephrinergic neurotransmission. Eur J Pharmacol. 2023 Jan 15:939:175454.

CAS Number: 4168-17-6

Molecular Weight: 486.51

Compound Purity: 99.92

Research Area: Cancer; Neurological Disease; Cardiovascular Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)/H2O : 5 mg/mL (ultrasonic;warming;adjust pH to 3 with HCl;heat to 60°C)

Target: Calcium Channel

• Artikelnummer: MEXHY-N0252A-100
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N0252A-100
• Green Labware: Nein
• Verpackungseinheit: 100 mg
• Mengeneinheit: STK