Celastramycin A (isomer), CAS 491600-94-3

Product Description: Celastramycin A isomer is an isomer of Celastramycin A (HY-122292), an antibiotic against Gram-negative bacteria and Mycobacterium tuberculosis with an MIC of 0.05-3.1 μg/mL. Celastramycin A exerts immunosuppressive effects in Drosophila ex vivo via the immunodeficiency pathway (IC50 of 8 ng/mL), inhibits human innate immune responses via the TNF-α pathway, and inhibits IL-8 production in HUEVC with an IC50 of 60 ng/mL[1][2].

Formula: C17H18Cl3NO3

References: [1]Pullen C, et al., New and bioactive compounds from Streptomyces strains residing in the wood of Celastraceae. Planta. 2002 Nov;216(1):162-7. [Content Brief]/[2]Kikuchi H, et al., Revised structure and synthesis of celastramycin a, a potent innate immune suppressor. Org Lett. 2009 Apr 16;11(8):1693-5. [Content Brief]

CAS Number: 491600-94-3

Molecular Weight: 390.69

Research Area: infection

Target: Antibiotic;Bacterial

• Artikelnummer: MEXHY-N12905-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N12905-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK