Cerulenin, CAS 17397-89-6

Product Description: Cerulenin, a potent, natural inhibitor of fatty acid synthase (FASN), is an epoxide produced by the fungus Cephalosporium caeruleus. Cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. Cerulenin has antifungal and antitumor activies[1][2][3][4].

Applications: Metabolism-sugar/lipid metabolism

Formula: C12H17NO3

References: [1]Bitencourt TA, et al. Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. BMC Complement Altern Med. 2013 Sep 17;13:229./[2]Tian D, et al. Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability. Cardiovasc Diabetol. 2012 Nov 21;11:144./[3]Cheng G, et al. Cerulenin blockade of fatty acid synthase reverses hepatic steatosis in ob/ob mice. PLoS One. 2013 Sep 27;8(9):e75980./[4]Jeong NY, et al. Fatty acid synthase inhibitor cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis. Apoptosis. 2013;18(2):226-237.

CAS Number: 17397-89-6

Molecular Weight: 223.27

Compound Purity: 99.52

Research Area: Infection; Metabolic Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Antibiotic;Apoptosis;Fatty Acid Synthase (FASN);Fungal

• Artikelnummer: MEXHY-A0210-25
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-A0210-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK