Cinchonine, CAS 118-10-5

Product Description: Cinchonine is a natural compound present in Cinchona bark with antimalarial, antitumor, anti-inflammatory, anti platelet-aggregation and anti-obesity properties. Cinchonine inhibits cells proliferation and autophagy and induces apoptosis through activation of Caspase-3. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells[1].

Applications: Cancer-programmed cell death

Formula: C19H22N2O

References: [1]Qi Y, et al., Cinchonine induces apoptosis of HeLa and A549 cells through targeting TRAF6. J Exp Clin Cancer Res. 2017 Feb 23;36(1):35./[2]Jin ZL, et al., Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15(6):5046-5050./[3]Wang H, et al., Cinchonine exerts anti-tumor and immunotherapy sensitizing effects in lung cancer by impairing autophagic-lysosomal degradation. Biomed Pharmacother. 2023 Aug;164:114980./[4]Jung SA, et al., Cinchonine Prevents High-Fat-Diet-Induced Obesity through Downregulation of Adipogenesis and Adipose Inflammation. PPAR Res. 2012;2012:541204./[5]Jo YJ, et al., Cinchonine inhibits osteoclast differentiation by regulating TAK1 and AKT, and promotes osteogenesis. J Cell Physiol. 2021 Mar;236(3):1854-1865./[6]Shah BH, et al., The inhibitory effect of cinchonine on human platelet aggregation due to blockade of calcium influx. Biochem Pharmacol. 1998 Oct 15;56(8):955-60./[7]Rani R, et al., Intracellular ROS production and apoptotic effect of quinoline and isoquinoline alkaloids on the growth of Trypanosoma evansi. Acta Trop. 2023 Sep;245:106980./[8]Jin ZL, et al. Cinchonine activates endoplasmic reticulum stress-induced apoptosis in human liver cancer cells. Exp Ther Med. 2018 Jun;15(6):5046-5050.

CAS Number: 118-10-5

Molecular Weight: 294.39

Compound Purity: 99.56

Research Area: Cancer; Inflammation/Immunology; Others

Solubility: DMSO : 4.76 mg/mL (ultrasonic)

Target: Apoptosis;Autophagy;Calcium Channel;Caspase;Parasite

• Artikelnummer: MEXHY-Y0152-5G
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-Y0152-5G
• Green Labware: Nein
• Verpackungseinheit: 5 g
• Mengeneinheit: STK