Collismycin A, CAS 158792-24-6

Product Description: Collismycin A is a bacterial metabolite originally isolated from Streptomyces that has diverse biological activities, including antibacterial, antiproliferative, and neuroprotective properties. It is active against a variety of bacteria (MICs=6.25 and 100 μg/mL) and fungi (MICs=12.5-100 μg/mL). It inhibits proliferation of A549 lung, HCT116 colon, and HeLa cervical cancer cells (IC50s=0.3, 0.6, and 0.3 μM, respectively) and NIH373 fibroblasts (IC50=56.6 μM) but not MDA-MD-231 breast cancer cells (IC50=>100 μM). Collismycin A forms a complex with Fe(II) and Fe(III) at a 2:1 ratio, and the addition of iron ions inhibits the antiproliferative effect of collismycin A on HeLa cells, an effect that does not occur with the addition of zinc, manganese, copper, or magnesium ions.3 Collismycin A (1 μM) prevents apoptosis in the brain region of zebrafish larvae by 44% in a model of neuronal cell death induced by all-trans retinoic acid.

Applications: COVID-19-immunoregulation

Formula: C13H13N3O2S

References: [1]Gomi, et al. Novel antibiotics SF2738A, B and C, and their analogs produced by Streptomyces sp. J. Antibiot. (Tokyo) 47(12), 1385-1394 (1994).

CAS Number: 158792-24-6

Molecular Weight: 275.33

Research Area: Infection

Target: Bacterial

• Artikelnummer: MEXHY-138185-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-138185-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK