D-Kynurenine, CAS 13441-51-5

Product Description: D-kynurenine, a metabolite of D-tryptophan, can serve as the bioprecursor of kynurenic acid (KYNA) and 3-hydroxykynurenine. D-Kynurenine is an agonist for G protein-coupled receptor, GPR109B. D-Kynurenine is a substrate in a fluorometric assay of D-amino acid oxidase. D-kynurenine promotes epithelial-to-mesenchymal transition via activating aryl hydrocarbon receptor (AHR)[1][2][3][4].

Applications: Cancer-programmed cell death

Formula: C10H12N2O3

References: [1]Wang XD, et al. A method for the determination of D-kynurenine in biological tissues. Anal Bioanal Chem. 2013 Dec;405(30):9747-54./[2]Irukayama-Tomobe Y, et al. Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3930-4./[3]Kozaki A, et al. Fluorimetric assay for D-amino acid oxidase activity in rat brain homogenate by using D-kynurenine as a substrate. Biosci Trends. 2012 Oct;6(5):241-7./[4]Duan Z, et al. Promoting epithelial-to-mesenchymal transition by D-kynurenine via activating aryl hydrocarbon receptor. Mol Cell Biochem. 2018 Nov;448(1-2):165-173.

CAS Number: 13441-51-5

Molecular Weight: 208.21

Compound Purity: 99.36

Research Area: Cancer

Solubility: H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C)

Target: Aryl Hydrocarbon Receptor;Endogenous Metabolite

• Artikelnummer: MEXHY-W014502-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-W014502-10.1
• Green Labware: Nein
• Verpackungseinheit: 10mM/1mL
• Mengeneinheit: STK